Middle-age Asian male with cerebral venous thrombosis after COVID-19 AstraZeneca vaccination

Che-Yu Guan; Shi-Hung Tsai; Ju-Sing Fan; Yu-Kai Lin; Chih-Chun Kao

doi:10.1016/j.ajem.2021.07.011

Middle-age Asian male with cerebral venous thrombosis after COVID-19 AstraZeneca vaccination

Am J Emerg Med. 2022 Jan:51:427.e3-427.e4. doi: 10.1016/j.ajem.2021.07.011. Epub 2021 Jul 8.

Authors

Che-Yu Guan¹, Shi-Hung Tsai², Ju-Sing Fan³, Yu-Kai Lin⁴, Chih-Chun Kao⁵

Affiliations

¹ Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Emergency Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, ROC; School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
² Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
³ School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
⁴ Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
⁵ Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address: rosty.kao@gmail.com.

Abstract

Vaccine-associated cerebral venous thrombosis has become an issue following the extensive vaccination program of the Coronavirus Disease of 2019 (COVID-19) Vaccine AstraZeneca (ChAdOx1 vaccine). The importance of early diagnosis should be emphasized due to the high mortality rate without appropriate treatment. Young female populations in western countries have been reported to be at a greater risk of this vaccine related thrombotic event, but cases in East Asia are lacking. Herein, we present the first case of cerebral venous sinus thrombosis 10 days after ChAdOx1 vaccination in a middle-age Asian male in Taiwan.

Keywords: COVID19; Cerebral venous sinus thrombosis; ChAdOx1 vaccine; Emergency department; Thrombocytopenia.

Publication types

Case Reports

MeSH terms

COVID-19 / prevention & control*
ChAdOx1 nCoV-19 / adverse effects*
Humans
Intracranial Thrombosis / chemically induced*
Male
Middle Aged
Vaccination / adverse effects*

Substances

ChAdOx1 nCoV-19