A young man with smoldering multiple myeloma died of hypotensive shock 2.5 days after severe acute respiratory syndrome coronavirus 2 vaccination. Clinical findings suggested systemic capillary leak syndrome (SCLS); the patient had experienced a previous suspected flare episode. History of SCLS may indicate higher risk for SCLS after receiving this vaccine.
Keywords: Ad26.COV2.S; COVID-19; COVID-19 vaccine; Clarkson disease; SARS-CoV-2; coronavirus disease; monoclonal gammopathy; multiple myeloma; respiratory infections; severe acute respiratory syndrome coronavirus 2; systemic capillary leak syndrome; vaccines; viruses.